Publications – Guiry Research Group

M. de Gaetano, C. Tighe, K. Gahan, A. Zanetti, J. Chen, J. Newson, A.Cacace, M. Marai, A. Gaffney, E. Brennan, P. Kantharidis, M. E. Cooper, X. Leroy, M. Perretti, D. Gilroy, C. Godson, P. J. Guiry

J. Med. Chem. 2021, 64, 13, 9193–9216

Further Developments and Applications of Oxazoline-Containing Ligands in Asymmetric Catalysis

R. Connon, B. Roche, B. V. Rokade, P. J. Guiry

Chem. Rev. 2021, 121, 11, 6373–6521

The preparation of ferrocene-containing phosphinamine ligands possessing central and planar chirality and their application in palladium-catalysed allylic substitution

K. Meaney, R. Goddard, R. P. J. Bronger, P. J.Guiry

Tetrehedron. 2021, 90, 132088

Recent Advances in Enantioselective Pd-Catalysed Allylic Substitution: From Design to Applications.

O. Pamies, J. Margalef, S. Canellas, J. James, E. Judge, P. J. Guiry,
C. Moberg, J.-E. Bäckvall, A. Pfaltz, M. A. Pericas, M. Diéguez.

Chem. Rev. 2021, 121, 8, 4373–4505

Catalytic Asymmetric Transformations of Oxa- and Azabicyclic Alkenes.

S. V. Kumar, A. Yen, M. Lautens, P. J. Guiry

Chem. Soc. Rev. 2021, 50, 3013-3093

Therapeutic potential of the FPR2/ALX agonist AT-01-KG in the resolution of articular inflammation

I. Galvão, E. M.Melo, V. L. S. de Oliveira, J. P. Vago, C. Queiroz-Junior, M. Gaetano, E. Brennan, K. Gahan, P. J. Guiry, C. Godson, M. M. Teixeira

Pharmacological Research, 2021, 165, 105445

2020

Recent Developments in the Synthesis and Applications of Chiral Ferrocene Ligands and Organocatalysts in Asymmetric Catalysis

L. Cunningham, A. Benson, P. J. Guiry

Org. Biomol. Chem. 2020, 18, 9329-9370

Advances in Decarboxylative Palladium-Catalyzed Reactions of Propargyl Electrophiles

C. Q. O’Broin, P. J. Guiry

J. Org. Chem. 2020, 85, 16, 10321–10333

Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells

L. Cunningham, Y. Wang, C. Nottingham, J. Pagsulingan, G. Jaouen, M. McGlinchey, P. J. Guiry

ChemBioChem, 2020, 21, 2974-2981

Synthesis of α-Aryl Oxindoles by Friedel–Crafts Alkylation of Arenes

B. Rokade, P. J. Guiry

J. Org. Chem. 2020, 85, 9, 6172-6180

Recent advances in the development of one-pot/multistep syntheses of3,4-annulated indoles

R. Connon, P. J. Guiry

Tetrahedron Letters 2020, 61, 151696

Synthesis of 2-Amino-1,3-dienes from Propargyl Carbonates via Palladium-Catalyzed Carbon–Nitrogen Bond Formation

C. Q. O’Broin, P. J. Guiry

Org. Lett. 2020, 22, 3, 879-883

Synthetic and mechanistic studies in enantioselective allylic substitutions catalysed by palladium complexes of a modular class of axially chiral quinazoline-containing ligands

A.-M. Carroll, M. McCarthy, P. M. Lacey, C. P. Saunders, D. J. Connolly, A. Farrell, B. V. Rokade, R. Goddard, P. Fristrup, P.-O. Norrby, P. J. Guiry

Tetrahedron, 2020, 76, 130780

2019

A Base-Promoted One-Pot Asymmetric Friedel–CraftsAlkylation/Michael Addition of 4-Substituted Indoles

R. Connon, L. Carroll, P. J. Guiry

Syntheses, 2019

Development of and recent advances in asymmetric A3 coupling

B. Rokade, J. Barker, P. J. Guiry

Chem. Soc. Rev., 2019, 48, 4766-4790

A Tandem Asymmetric Friedel–Crafts Alkylation/Michael Addition: Synthesis of Novel Ergoline Derivatives

R. Connon, P. J. Guiry

Eur. J. Org. Chem. 2019, 5950–5954

Construction of All-Carbon Quaternary Stereocenters by Palladium-Catalyzed Decarboxylative Propargylation

C. Q. O’Broin, P. J. Guiry

Org. Lett. 2019, 21, 14, 5402-5406

Enantioselective Catalytic Asymmetric A3 Coupling with Phosphino-Imidazoline Ligands

B. Rokade, P. J. Guiry

J. Org. Chem. 2019, 84, 5763−5772

Pd‐Catalyzed Decarboxylative Asymmetric Protonation (DAP) Using Chiral PHOX Ligands vs. Chiral Ligand‐Free Conditions Employing (1R,2S)(–)‐Ephedrine – A Comparison Study

J. James, R. Akula, P. J. Guiry

Eur. J. Org. Chem. 2019, 2421–2427

Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation: Development, Mechanistic Understanding and Recent Advances

J. James, M. Jackson, P. J. Guiry

Adv. Synth. Catal. 2019, 361, 3016 –3049

A mechanistic rationale for the outcome of Sonogashira cross-coupling of 9-bromoanthracene and ethynyltrimethylsilane: An unexpected product 4-(9-anthracenyl)-1,3-bis(trimethylsilyl)-3-en-1-yne

K. Nikitin, H. Müller-Bunz, P. J. Guiry and M. J. McGlinchey

J. Organomet. Chem., 2019, 880, 1-6

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

M. de Gaetano, E. Butler, K. Gahan, A. Zanetti, M. Marai, J. Chen, A. Cacace, E. Hams, C. Maingot, A. McLoughlin, E. Brennan, X. Leroy, C. E. Loscher, P. Fallon, M. Perretti, C. Godson and P. J. Guiry

Eur. J. Med. Chem., 2019, 162, 80-108

2018

Development of and Recent Advances in Pd-Catalyzed Decarboxylative Asymmetric Protonation

C. Kingston, J. James, P. J. Guiry

J. Org. Chem., 2019, 84, 473-485

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease

E. P. Brennan, M. Mohan, A. McClelland, C. Tikellis, M. Ziemann, A. Kaspi, S. P. Gray, R. Pickering, S. Min Tan, S. Tasadaque Ali-Shah, P. J. Guiry, A. El-Osta, K. Jandeleit-Dahm, M/ E. Cooper, C. Godson and P Kantharidis

J. Am. Soc. Nephrol., 2018, 29, 1437-1448

Axially Chiral P,N-Ligands: Some Recent Twists and Turns

B. V. Rokade and P. Guiry

ACS Catal., 2018, 8, 624–643

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

E. P. Brennan, M. Mohan, A. McClelland, M. de Gaetano, C. Tikellis, M. Marai1, D. Crean, A. Dai, O. Beuscart, S. Derouiche, S.P. Gray, R. Pickering, M. Tan, M. Godson-Treacy, S. Sheehan, J.F. Dowdall, M. Barry, O. Belton, S.T. Ali-Shah, P. J. Guiry, K. Jandeleit-Dahm, M.E. Cooper, C. Godson1 and P. Kantharidis

Diabetes, 2018, 67, db171317

Axially chiral tridentate isoquinoline derived ligands for diethylzinc addition to aldehydes

B. A. Sweetman and P. J. Guiry

Tetrahedron, 2018, 74, 5567-5581

Pd‐Catalyzed Decarboxylative Asymmetric Protonation of Sterically Hindered α‐Aryl Lactones and Dihydrocoumarins

J. James, R. Akula, P. J. Guiry

Adv. Synth. Catal, 2018, 360, 3138-3149

Enantioselective Synthesis of Sterically Hindered Tertiary α‐Aryl Oxindoles via Palladium‐Catalyzed Decarboxylative Protonation. An Experimental and Theoretical Mechanistic Investigation

M.Biosca, M. Jackson, M. Magre, O. Pàmies, P. Norrby, M. Diéguez and P. J. Guiry

Adv. Synth. Catal, 2018, 360, 3124-3137

2017

Protective Effect of Let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis

E. Brennan, B. Wang, A. McClelland, M. Mohan,M. Marai, O. Beuscart, S. Derouiche, S. Gray, R. Pickering, C. Tikellis, M. de Gaetano, M. Barry, O. Belton, S. Tasadaque Ali-Shah, P. Guiry, K. AM Jandeleit-Dahm, M. E. Cooper, C. Godson and P Kantharidis

Diabetes, 2017, 66, 2266-2277

Application of a One-Pot Friedel–Crafts Alkylation/Michael Addition Methodology to the Asymmetric Synthesis of Ergoline Derivatives

C. Despotopoulou, S. C. McKeon, R. Connon, V. Coeffard, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2017, 45, 6734–6738

Enantioselective Synthesis of Sterically Hindered α-allyl–α-aryl Oxindoles via Palladium-Catalysed Decarboxylative Asymmetric Allylic Alkylation

M. Jackson, C. Q. O’Broin, H. Müller-Bunz and P. J. Guiry

Org. Biomol. Chem., 2017, 15, 8166

Controlling the Reactivity of Ferrocenyl Carbocations: Routes to Enantiomerically Pure Chlorophosphites and Solid-State Characterization of a Benzopentalene Dimer

C. Nottingham, H. Müller-Bunz, M. J. McGlinchey and P. J. Guiry

Eur. J. Org. Chem., 2017, 19, 2848–2854

A Quininib Analogue and Cysteinyl Leukotriene Receptor Antagonist Inhibits Vascular Endothelial Growth Factor (VEGF)-independent Angiogenesis and Exerts an Additive Antiangiogenic Response with Bevacizumab

T. Butler, A. L. Reynolds, M. Tosetto, E. T. Dillon, P. J. Guiry, G. Cagney, J. O’Sullivan and B. N. Kennedy

J. Biol. Chem., 2017, 292, pp. 3552-3567

Enantiodivergent Synthesis of Tertiary α-Aryl 1-Indanones: Evidence Toward Disparate Mechanisms in the Palladium-Catalyzed Decarboxylative Asymmetric Protonation

C. Kingston and P. J. Guiry

J. Org. Chem., 2017, 82, pp. 3806-3819

Diastereofacial p-Stacking as an Approach To Access an Axially Chiral P,N-Ligand for Asymmetric Catalysis

B. Rokade and P. J. Guiry

ACS Catal., 2017, 7, pp. 2334–2338

Highly Enantioselective Construction of Sterically Hindered α-Allyl-α-Aryl Lactones via Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation

J. James, and P. J. Guiry

ACS Catal., 2017, 7, pp. 1397-1402

2016

Enantioselective Synthesis of a-Allyl-a-Aryl Dihydrocoumarins and 3-Isochromanones via Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation

R. Akula and P. J. Guiry

Org. Lett., 2016, 18, pp. 5472-5475

A Family of Chiral Ferrocenyl Diols: Modular Synthesis, Solid-State Characterization, and Application in Asymmetric Organocatalysis

C. Nottingham, H. Müller-Bunz and P. J. Guiry

Angew. Chem. Int. Ed., 2016, 55, pp. 11115-11119

Highly Enantioselective Formation of α-Allyl-α-Arylcyclopentanones via Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation

R. Akula, R. Doran and P. J. Guiry

Chem. Eur. J., 2016, 22, pp. 9938-9942

Intramolecular Heck Reactions in Science of Synthesis: Metal Catalyzed Cyclization Reactions

S. Jammi, C. Nottingham and P. J. Guiry

Ma, S.; Gao, S., Eds.; Thieme: Stuttgart, 2016; Vol. 1, pp. 55-93

2015

Synthesis of Bis(oxazoline) Ligands Possessing C-5 gem-Disubstitution and Their Application in Asymmetric Friedel–Crafts Alkylations

Steven O’Reilly, Miriam Aylward, Caoimhe Keogh-Hansen, Brian Fitzpatrick, Helen A. McManus, Helge Müller-Bunz, and Patrick J. Guiry

J. Org. Chem., 2015, 80 (20), pp. 10177–10186

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Synthesis of Ferrocene Oxazoline N,O ligands and Their Application in Asymmetric Ethyl- and Phenylzinc Additions to Aldehydes

Chris Nottingham, Robert Benson, Helge Müller-Bunz, and Patrick J. Guiry

J. Org. Chem., 2015, 80 (20), pp. 10163–10176

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Exploiting the gem-Disubstitution Effect in FcPHOX and HetPHOX P,N Ligands: Synthesis and Applications in Pd-Catalyzed Intermolecular Heck Reactions

Dennis McCartney, Chris Nottingham, Helge Müller-Bunz, and Patrick J. Guiry

J. Org. Chem., 2015, 80 (20), pp. 10151–10162

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Lipoxin A₄ Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

Emma Börgeson, Andrew M.F. Johnson, Yun Sok Lee, Andreas Till, Gulam Hussain Syed, Syed Tasadaque Ali-Shah, Patrick J. Guiry, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Kumar Sharma, Catherine Godson

Cell Metabolism, 2015, 22, pp. 125-137

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RNA interference screening identifies a novel role for PCTK1/CDK16 in medulloblastoma with c-Myc amplification

P. Wiek, Z. Leni, F. Salm, V. Dimitrova, B. Styp-Rekowska, G. Chiriano, M. P. Carroll, K. Höland, V. Djonov, L. Scapozzaand P. J. Guiry, Arcaro, A.

Oncotarget, 2015, 6, pp. 116-129

2014

Catalytic Asymmetric Synthesis of Sterically Hindered Tertiary α-Aryl Ketones

Robert Doran and Patrick J. Guiry

J. Org. Chem., 2014, 79 (19), pp. 9112–9124

Recent applications of C1-symmetric bis(oxazoline)-containing ligands in asymmetric catalysis

Steven O’Reilly and Patrick J. Guiry

Synthesis, 2014, 46, 722.

Asymmetric synthesis and biological evaluation of 1,3- and 1,4-disubstituted benzo-type lipoxin A4 analogues

Gavin G. Haberlin, Ciara McCarthy, Robert Doran, Christine E. Loscher and Patrick J. Guiry

Tetrahedron, 2014, 70, 38, pp. 6859-6869

Quinap and Congeners: Atropos PN ligands for Asymmetric Catalysis

Elena Fernández, Patrick J. Guiry, Kieran P. T. Connole, John M. Brown

J. Org. Chem., 2014, 79 (12), pp. 5391–5400

Asymmetric synthesis of both enantiomers of a δ-lactone analogue of muricatacin

Doran, R., Guiry, P. J.

Synthesis (2014) 46, 761.

P,N ligands in asymmetric catalysis

Carroll, M. P., Guiry, P. J.

Chem. Soc. Rev. (2014) 43, 819.

A Stereoselective Switch: Enantiodivergent Approach to the Synthesis of Isoflavanones

R. Doran, M. P. Carroll. R. Akula, B. F. Hogan, M. Martins, S. Fanning and P. J. Guiry

Chem. Eur. J., 2014, 20, pp. 15354-15359

Vinyl substitutions with organopalladium intermediates in Comprehensive Organic Synthesis

E. M. Butler, R. Doran, C. M. Wilson and P. J. Guiry

Eds. Molander, G. A., Knochel, P., 2nd Edition, Vol. 4, Oxford: Elsevier, 2014, pp. 810-890

2013

Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands

Carroll, M. P., Guiry, P. J., Brown, J. M.

Org. Biomol. Chem. (2013) 11, 4591.

Production of a Chiral Alcohol, 1-(3,4-dihydroxyphenyl)ethanol, by mushroom tyrosinase

S. J. Brooks, J. Nikodinovic, L. Martin, E. M. Doyle, T. O’Sullivan, P. J. Guiry, L. Coulombel, Z. Li, and K. E. O’Connor

Biotech. Lett., 2013, 35, pp. 779-783

Lipoxins Attenuate Renal Fibrosis by Inducing Let-7c and Suppressing TGF-b1

E. P. Brennan, K. Nolan, E. Börgeson, O. S. Gough, N. G. Docherty, D. F. Higgins, M. Murphy, S. T. Ali Shah, P. J. Guiry, D. A. Savage, A. P. Maxwell, F. Martin, and C. Godson

J. Am. Soc. Nephrol., 2013, 24, pp. 627-637

Stereoselective Nozaki-Hiyama-Kishi Reaction

G. C. Hargaden and P. J. Guiry

Stereoselective Synthesis of Drugs and Natural Products, Eds. Andrushko, V.; Andrushko, N., Wiley-VCH, 2013, Chapter 12, Vol. 1, pp. 347-368

2012

Enantioselective construction of sterically hindered tertiary α-aryl ketones: a catalytic asymmetric synthesis of isoflavanones

Carroll, M. P., Mueller-Bunz, H., Guiry, P. J.

Chem. Commun. (Cambridge, U. K.) (2012) 48, pp. 11142.

The medicinal chemistry of stable synthetic leukotriene B3 and B4 analogues

P. J. Guiry and C. Barth

Fut. Med. Chem., 2012, 4, pp. 1007-1014

Enantioselective Construction of Sterically Hindered Tertiary α-Aryl Ketones: A Catalytic Asymmetric Synthesis of Isoflavanones

M. Carroll, H. Müller-Bunz and P. J. Guiry

Chem. Comm., 2012, 48, pp. 11142-11144

Intermolecular Reactions of Cyclic Alkenes: Enantioselective and Non-Enantioselective Transformations

V. Coeffard and P. J. Guiry

Cross-Coupling and Heck-type Reactions, Volume 3: 3.1.1.4 Science of Synthesis, Eds. Larhed, M.; Odell, L. R., Stuttgart, 2012, pp. 303-344

Palladium-catalyzed enantioselective allylic substitution

L. Milhau and P. J. Guiry

Topics in Organometallic Chemistry, Ed. U. Kazmaier, Springer-Verlag, 2012, 38, 9 pp. 5-154

Development of the Asymmetric Nozaki-Hiyama-Kishi Reaction

G. C. Hargaden and P. J. Guiry

Innovative Catalysis In Organic Synthesis, Ed. P. Andersson, Wiley-VCH, 2012, pp. 279-307

2011

Novel Palladium-free synthesis of a key Quinazolinap precursor

L. Milhau, and P. J. Guiry

Synlett., 2011, 383-385

Leukotriene B₄/Antimicrobial Peptide LL-37 Proinflammatory Circuits Are Mediated by BLT1 and FPR₂/ALX, and Are Counter-Regulated by Lipoxin A₄ and Resolvin E1

M. Wan, C. Godson, P. J. Guiry, B. Agerberth and J. Haeggström

FASEB 2011, 25, 1697-1705

Palladium-catalyzed three-component transformation of homoallenols: a regio- and stereoselective route to 1,5-amino alcohols

M. Aylward, V. Coeffard, and P. J. Guiry

J. Org. Chem., 2011, 76, 3536-3538

Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis

E. Börgeson, N. G. Docherty, M. Murphy, K. Rodgers, A. Ryan, T. O’Sullivan, P. J. Guiry, R. Goldschmeding, D. F. Higgins, and C. Godson

FASEB 2011, 25, 2967-2979

Asymmetric Synthesis of (+)-Tanikolide and b-Methyl-substituted Analogues of (+)-Tanikolide and (-)-Malyngolide

R. Doran, L. Duggan, S. Singh, C. D. Duffy and P. J. Guiry

Eur. J. Org. Chem., 2011, 7097-7106

The Synthesis of Thiazoline-Oxazoline Ligands and Their Applications in Asymmetric Catalysis

S. McKeon, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2011, 7107-7115

Enantioselective [2+2+2] Cycloisomerisation of Alkynes in the Synthesis of helicenes: The Search For Effective Chiral Ligands

I. G. Stará, A. Andronova, A. Kollárovic, S. S. Vyskocil, S. Jugé, G. C. Lloyd-Jones, P. J. Guiry and I. Stary

Collect. Czech. Chem. Commun., 2011, 76, 2005-2022

The Asymmetric Heck and Related Reactions

P. J. Guiry and D. Mc Cartney

ChemSocRev. 2011, 40, 5122-5150

2010

Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A₄ Analogues

C. D. Duffy, P. Maderna, C. McCarthy, C. E. Loscher, C. Godson and P. J. Guiry

ChemMedChem., 2010, 5, 517-522

A Short And Efficient Asymmetric Synthesis Of (–)-Frontalin, (–)-Exo- Isobrevicomin And Volatile Contributor Of Beer-Aroma

S. Singh and P. J. Guiry

Tetrahedron, 2010, 66, 5701-5706

Rhodium-Catalysed Hydroboration Employing New Quinazolinap Ligands; an Investigation into Electronic Effects

A. C. Maxwell, S. P. Flanagan, R. Goddard and P. J. Guiry

Tetrahedron: Asymmetry, 2010, 21, 1458-1473

Synthesis and post-resolution modification of new axially chiral ligands for asymmetric catalysis

W. J. Fleming, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2010, 5996-6004

Recent Advances in the Chemistry and Biology of Stable Synthetic Lipoxin Analogues

P. J. Guiry and C. D. Duffy

MedChemComm, 2010, 1, 249-26

Recent Developments In Ligand Design For The Asymmetric Intermolecular Heck Reaction

P. J. Guiry and V. Coeffard

Curr. Org. Chem., 2010, 14, 212-229

2009

The Synthesis of New HetPHOX Ligands and Their Application to the Intermolecular Asymmetric Heck Reaction

M. O. Fitzpatrick, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2009, 1889-1895

A Novel, Chemoselective and Efficient Microwave-Assisted Deprotection of Silyl Ethers using Selectfluor

S. T. Ali Shah, S. Singh and P. J. Guiry

J. Org. Chem., 2009, 74, 2179-2182

A Facile Synthesis of both Enantiomers of 6-Acetoxy-5-hexadecanolide, a Major Component of Mosquito Oviposition Attractant Pheromones

S. Singh and P. J. Guiry

Eur. J. Org. Chem., 2009, 1896-1901

Axially Chiral P-N Ligands for the Copper Catalyzed b-Borylation of a,b-Unsaturated Esters

W. J. Fleming, H. Müller-Bunz, V. Lillo, E. Fernández and P. J. Guiry

Org. Biomol. Chem. 2009, 7, 2520-2524

The Synthesis of New Oxazoline-Containing Bifunctional Catalysts and their Application in the Addition of Diethylzinc to Aldehydes

V. Coeffard, H. Müller-Bunz and P. J. Guiry

Org. Biomol. Chem., 2009, 7, 1723-1734

Microwave-Assisted Synthesis of Substituted Tetrahydropyrans Catalysed by ZrCl₄ and its Application in the Asymmetric Synthesis of Exo– and Endo-brevicomin

S. Singh and P. J. Guiry

J. Org. Chem., 2009, 74, 5758-5761

First Regio- and Enantioselective Chromium-catalyzed Homoallenylation of Aldehydes

V. Coeffard, M. Aylward and P. J. Guiry

Angew. Chem. Int. Ed Engl., 2009, 48, 9152-9155

New Thiazoline-Oxazoline Ligands and Their Application in the Asymmetric Friedel-Crafts Reaction

S. McKeon, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2009, 4833-4841

Expanding the Substrate Scope for Metal Catalyzed Asymmetric Carbon-Boron Bond Formation

P. J. Guiry

ChemCatChem., 2009, 1, 233-235

Recent Developments in the Application of Oxazoline-Containing Ligands in Asymmetric Catalysis

P. J. Guiry and G. Hargaden

J. Chem. Rev., 2009, 109, 2505-2550

Ligand Design for the Intermolecular Asymmetric Heck Reaction

M. O. Fitzpatrick, A. G. Coyne and P. J. Guiry

The Mizoroki-Heck Reaction, Fitzpatrick, Ed. M. Oestrich, Wiley-VCH, 2009, pp. 405-432

2008

Synthesis of Non-Symmetric Bis(oxazoline) Ligands and their Application in the Catalytic Enantioselective Nozaki-Hiyama-Kishi Allylation of Benzaldehyde

G. C. Hargaden, T. P. O’Sullivan and P. J. Guiry

Org. Biomol. Chem., 2008, 6, 562-566

The Chemoselective and Efficient Deprotection of Silyl Ethers using Trimethylsilyl Bromide

S. T. Ali Shah and P. J. Guiry

Org. Biomol. Chem., 2008, 6, 2168-2172

ZrCl₄ as An Efficient Catalyst for a Novel One-Pot Protection/ deprotection Synthetic Methodology

S. Singh, C. Duffy, S. T. Ali Shah and P. J. Guiry

J. Org. Chem., 2008, 73, 6429-6432.

Electronically Varied Quinazolinaps for Asymmetric Catalysis

A. Maxwell, C. Franc, L. Pochain, H. Müller-Bunz and P. J. Guiry

Org. Biomol. Chem. 2008, 6, 3848-3853

Synthesis, Resolution, and Application of Cyclobutyl- and Adamantyl-Quinazolinap Ligands

T. Fekner, H. Müller-Bunz and P. J. Guiry

Eur. J. Org. Chem., 2008, 5055-5066

The Development and Application of Rhodium-Catalysed Hydroboration of Alkenes

A. G. Coyne and P. J. Guiry

Modern Reduction Methods, Eds. P.G. Andersson, I. Munslow, Wiley-VCH, 2008, Chapter 3, pp. 65-84

2007

Aromatic Lipoxin A₄ and Lipoxin B₄ Analogues Display Potent Biological Activities

T. P. O’Sullivan, K. S. A. Vallin, S. T. Ali Shah, J. Fakhry, P. Maderna, M. Scannell, C. Godson and P. J. Guiry

J. Med. Chem., 2007, 50, 5894-5902

Rhodium Catalysed Asymmetric Hydrosilylation of Ketones using HETPHOX Ligands

A. G. Coyne and P. J. Guiry

Tetrahedron Lett., 2007, 48, 747-750

The Asymmetric Synthesis of b-Lactams: HETPHOX/ Cu(I) Mediated Synthesis via the Kinugasa Reaction

A. G. Coyne and P. J. Guiry

Tetrahedron: Asymmetry, 2007, 18, 199-207

The Application of Bis(oxazoline) Ligands in the Catalytic Enantioselective Methallylation of Aldehydes

G. C. Hargaden, H. A. McManus, P. G. Cozzi and P. J. Guiry

Org. Biomol. Chem., 2007, 5, 763-766

Comparative potencies of 3,4methylenedioxymethamphetamine (MDMA) analogues as inhibitors of [H-3] noradrenaline and [H-3]5-HT transport in mammalian cell lines

T. R. Montgomery, C. Buon, S. Eibauer, P. J. Guiry, A. K. Keenan and G. J. McBean

Brit J. Pharm., 2007, 152, 1121-1130

Aminophosphine-oxazoline and Phosphoramidite-oxazoline Ligands and Their Application in Asymmetric Catalysis

R. J. Bronger and P. J. Guiry

Tetrahedron: Asymmetry, 2007, 18, 1094-1102

New Proline-Oxazoline Ligands and their Application in the Asymmetric Nozaki-Hiyama-Kishi Reaction

G. C. Hargaden, H. Müller-Bunz and P. J. Guiry

Eur. J.Org. Chem., 2007, 4235-4243

The Development of the Asymmetric Nozaki-Hiyama-Kishi Reaction

P. J. Guiry and G. C. Hargaden

Adv. Syn. Cat., 2007, 349, 2407-2424

2006

Application of Tridentate Bis(oxazoline) Ligands in Catalytic Asymmetric Nozaki-Hiyama Allylation and Crotylation: An Example of High Enantioselection with a Non-C₂-Symmetric Bis(oxazoline) Ligand

H. A. McManus, P. G. Cozzi and P. J. Guiry

Adv. Syn. Cat., 2006, 348, 551-558

New Chiral Tridentate Ligands for Asymmetric Catalysis

K. Murtagh, B. Sweetman and P. J. Guiry

Pure and Applied Chem., 2006, 78, 311-320

The Application of HETPHOX Ligands to the Intramolecular Asymmetric Heck Reaction

M. O. Fitzpatrick, A. G. Coyne and P. J. Guiry

Synlett., 2006, 3150-3154

The Synthesis of N,O-Ferrocenyl Pyrrolidine-Containing Ligands And Their Application in Diethyl- and Diphenylzinc Addition to Aromatic Aldehydes

T. Ahern, H. Müller-Bunz and P. J. Guiry

J. Org. Chem., 2006, 71, 7596-7602

Synthesis and Application of Quinazoline–Oxazoline-Containing (Quinazox) Ligands

T. Fekner, H. Müller-Bunz and P. J. Guiry

Org. Lett. 2006, 8, 5109-5112

Substituent Effects in Asymmetric Catalysis

S. P. Flanagan and P. J. Guiry

J. Organomet. Chem., 2006, 691, 2125-2154

2005

Synthesis, Resolution and Racemisation Studies of New Tridentate Ligands for Asymmetric Catalysis

B. A. Sweetman, H. Müller-Bunz and P. J. Guiry

Tetrahedron Lett, 2005, 46, 4643-4646

The preparation and resolution of 2-(2-pyridyl)- and 2-(2-pyrazinyl)-Quinazolinap and their application in palladium-catalysed allylic substitution

S. P. Flanagan, R. Goddard and P. J. Guiry

Tetrahedron Symposium-in-print, 2005, 61, 9808-9821

Synthesis of Quinazolinones And Quinazolines

D. J. Connolly, D. Cusack, T. P. O’Sullivan and P. J. Guiry

Tetrahedron, 2005, 61, 10153-10202

Synthesis of Dihydrofurans Substituted in the 2-Position

T. G. Kilroy, T. P., O’Sullivan and P. J. Guiry

Eur. J. Org. Chem. 2005, 4929-4949

The Development of the Asymmetric Rhodium-catalysed Olefin Hydroboration

A.-M. Carroll, T. P. O’Sullivan and P. J. Guiry

Adv. Synth. Cat., 2005, 347, 609-631

2004

The Application of HETPHOX Ligands to the Asymmetric Intermolecular Heck Reaction

T. G. Kilroy, P. G. Cozzi, N. End and P. J. Guiry

Synlett, 2004, 106-110

The preparation of pyrrolidine-oxazoline containing ligands and their application in asymmetric transfer hydrogenation

H. A. McManus, S. Barry, P. G. Andersson and P. J. Guiry

Tetrahedron, 2004, 60, 3405-3416

The Application of HETPHOX Ligands to the Asymmetric Intermolecular Heck Reaction of 2,3-Dihydrofuran and 2,2-Disubstituted-2,3-Dihydrofurans

T. G. Kilroy, N. End, P.G. Cozzi and P. J. Guiry

Synthesis, 2004, 1879-1888

Preparation and Resolution of a Modular Class of Axially Chiral Quinazoline-containing Ligands and their Application in Asymmetric Rhodium-catalysed Olefin Hydroboration

D. J. Connolly. P.M. Lacey, M. McCarthy, C.P. Saunders, A.M. Carroll, R. Goddard and P. J. Guiry

J. Org. Chem., 2004, 69, 6572-6589

Recent Developments in the Application of Oxazoline-Containing Ligands in Asymmetric Catalysis

H. McManus and P. J. Guiry

Chem. Rev., 2004, 104, 4151-4202

The Development of Bidentate P-N ligands for Asymmetric Catalysis

P. J. Guiry and C. P. Saunders

Appl. Synth. Cat., 2004, 346, 497-537

The Development of the Intramolecular Asymmetric Heck reaction

P. J. Guiry and D. Kiely

Curr. Org. Chem., 2004, 8, 781-794

1-[4-(S)-tert-Butyl-2-oxazolin-2-yl]-2-(S)-(diphenylphosphino)ferrocene as a Ligand for the Palladium-Catalyzed Intermolecular Asymmetric Heck Reaction of 2,3-Dihydrofuran

T. G. Kilroy, Y. M. Malone and P. J. Guiry

Catalysts for Fine Chemicals, Eds. SM. Roberts, J. Xiao, J. Whittall and T. Pickett, Wiley, New York, 2004, Ch.5, pp.104-112

2003

From 2,3-Dihydrofuran to 2,2-Dialkyl-2,3-dihydrofurans: New Substrates for the Intermolecular Asymmetric Heck Reaction

T. G. Kilroy, A.J. Hennessy, D.J. Connolly, Y.M. Malone, A. Farrell, and P. J. Guiry

J. Mol. Cat. A: Chem., 2003, 196/1-2, 65-81

A comparison of palladium complexes of BINAP and diphenylphosphinooxazoline ligands in the catalytic asymmetric synthesis of cis-decalins

D. Kiely and P. J. Guiry

Tetrahedron Lett., 2003, 44, 7377-7380

Palladium complexes of phosphinamine ligands in the intramolecular asymmetric Heck reaction

D. Kiely and P. J. Guiry

J. Organomet. Chem., 2003, 687, 545

Category l (Organometallics), Volume 5 (Group 14 (Ge, Sn, P)), Product Class 3 (Lead Compounds), Product Subclasses 6-13

P. J. McCormack and P. J. Guiry

Science of Synthesis, Eds. Thomas, E. J.; Moloney, M. G., Houben-Weyl Thieme, 2003, pp. 653-712

2002

The preparation of ferrocene-containing phosphinamine ligands possessing central and planar chirality and their application in palladium-catalysed asymmetric allylic alkylation

A. Farrell, R. Goddard and P. J. Guiry

J. Org. Chem, 2002, 67, 4209-4217

In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4- methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine

J. E. J. Murphy, J.J. Flynn, D.M. Cannon, P.J. Guiry, P. McCormac, A.W. Baird, G.J. McBean, and A.K. Keenan

Eur. J. Pharmacol., 2002, 444, 61-67

A comparative study of diphosphine and phosphinamine palladium complexes on a new substrate for the intramolecular asymmetric Heck reaction

D. Kiely and P. J. Guiry

Tetrahedron Lett., 2002, 43, 9545-9547

The coupling of bulky, electron-deficient partners in aryl amination in the preparation of tridentate bis(oxazoline) ligands for asymmetric catalysis

H. A. McManus, and P. J. Guiry

J. Org. Chem., 2002, 67, 8566-8573

2001

Synthesis of Neoflavenes by Ligand Coupling Reactions with Aryllead Triacetates

D. M. X. Donnelly, J.P. Finet, P. J. Guiry, K. Nesbitt

Tetrahedron, 2001, 57, 413-423

A facile and versatile route to 2-substituted-4(3H)-quinazolinones and quinazolines

D. J. Connolly and P. J. Guiry

Synlett, 2001, 1707-1710

In vitro neuronal and vascular responses to 5-HT in rats chronically exposed to MDMA

D. Cannon, A. Keenan, P.J. Guiry, C. Buon, A. Baird and G.J. McBean

Brit. J. Pharmacol., 2001, 134, 1455-1460

Axially Chiral Ligands in Asymmetric Catalysis

M. McCarthy and P. J. Guiry

Tetrahedron, 2001, 57, 3809-3844

2000

A New Quinazoline-containing Axially Chiral Ligand For Asymmetric Catalysis

M. McCarthy and P. J. Guiry

Polyhedron, 2000, 19, 541-543

The Application of Palladium Complexes of Diphenylphosphinoferrocenyloxazoline Ligands to Catalytic Enantioselective Allylic Aminations

Y. M. Malone and P. J. Guiry

J. Organomet. Chem., 2000, 603, 110-115

Enantioselective Hydroboration of Alkenes Catalysed by Rhodium Complexes of the Axially Chiral (S)-2-Phenylquinazolinap

M. McCarthy, M.W. Hooper and P. J. Guiry

Chem Commun., 2000, 1333-1334

The Asymmetric Cyclohexenylation of 2,2-Dimethyl-2,3-dihydrofuran

A. J. Hennessy, Y.M. Malone and P. J. Guiry

Tetrahedron Lett., 2000, 41, 2261-2264

Synthesis and Resolution of 2-Methyl-quinazolinap, a New Atropismeric Phosphinamine Ligand for Asymmetric Catalysis

P. M. Lacey, C.M. McDonnell and P. J. Guiry

Tetrahedron Lett., 2000, 41, 2475-2478

A Thermospray Ionisation LC-MS guided isolation of a new sesquiterpene aryl ester from Armillaria novae-zelandiae’

P. A. Cremin, P.J. Guiry, J.L. Wolfender, K. Hostettmann and D.M.X. Donnelly

J. Chem. Soc., Perkin Trans. I, 2000, 2325-2329

Intermolecular asymmetric Heck reactions with 2,2-diethyl-2,3-dihydrofuran

A. J. Hennessy, D.J. Connolly, Y.M. Malone and P. J. Guiry

Tetrahedron Lett., 2000, 41, 7757-7761

Axially Chiral Phosphinamine Ligands in Asymmetric Catalysis

P. J. Guiry, M. McCarthy, P. M. Lacey, C. P. Saunders, S. Kelly, D. J. Connolly

Curr. Org. Chem., 2000, 4, 835-850

1999

The Preparation, Resolution and Chemistry of 1-(3,6-Dimethylpyrazin-2-yl)(2-, naphthyl)diphenylphosphine, an Axially Chiral Phosphinamine

M. McCarthy and P. J. Guiry

Tetrahedron, 1999, 55, 3061-3070

Synthesis of C-Ring Hydroxylated Neoflavonoids by Palladium-catalysed Ligand Coupling Reactions

D. M. Donnelly, J.P. Finet, P. J. Guiry and M.D. Rea

Synth. Commun., 1999, 29, 2719-2730

2,2-Dimethyl-2,3-dihydrofuran, a New Substrate for Intermolecular Asymmetric Heck Reactions

A. J. Hennessy, Y.M. Malone and P. J. Guiry

Tetrahedron Lett., 1999, 40, 9163-9166

The Preparation and Resolution of 2-Phenylquinazolinap; A New Axially Chiral Ligand for Asymmetric Catalysis

M. McCarthy, R. Goddard and P. J. Guiry

Tetrahedron: Asymmetry, 1999, 10, 2797-2807

trans-2,5-Dialkylpyrrolidinyl-containing Phosphinamines; Synthetic and Mechanistic Studies in Pd-Catalysed Asymmetric Allylic Alkylation

J. P. Cahill, D. Cunneen and P. J. Guiry

Asymmetry, 1999, 10, 4157-4173

1998

The Preparation of trans-2,5-Dialkylpyrrolidinylbenzyldiphenylphosphines: New Phosphinamine Ligands for Asymmetric Catalysis

J. P. Cahill, F. Bohnen, R. Goddard, C. Krüger and P. J. Guiry

Tetrahedron: Asymmetry, 1998, 9, 3831-3839

The Application of Pd-Complexes of trans-2,5-Dialkylpyrrolidinylbenzyldiphenyl phosphines to Enantioselective Allylic Alkylation

J. P. Cahill and P. J. Guiry

Tetrahedron: Asymmetry, 1998, 9, 4301-4306

The Application of Ir-Complexes of trans-2,5-Dialkylpyrrolidinylbenzyldiphenyl phosphines to the Enantioselective Reduction of Imines

J. P. Cahill, A. P. Lightfoot, R. Goddard, J. Rust and P. J. Guiry

Tetrahedron: Asymmetry, 1998, 9, 4307-4312

1997

The Asymmetric Heck Reaction: Recent Developments and Applications of New Palladium Diphenylphosphinopyrrolidine Complexes

J. P. Cahill, A. J. Hennessy and P. J. Guiry

Topics in Catalysis, 1997, 4, 311-326

1995

Steric and Electronic Requirements of Amide and Ester Groups in Benzylidenemalonates

J. C. P. Laing, P. J. Guiry and J. M. Brown

Tetrahedron, 1995, 51, 7423-7434

1994

Mechanistic and Synthetic Studies in Catalytic Allylic Alkylation with Palladium Complexes of 1-(2-Diphenylphosphino-1-naphthyl)isoquinoline

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron, 1994, 15, 4493-4507

Ortho-Arylation of 3,5-Di-tert-butylphenol with Aryllead(IV) Derivatives. A Facile synthesis of sterically Hindered Phenols

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

J. Chem. Soc., Perkin Trans. I, 1994, 2921

Bite Angle Dependence of the Rate of Reductive Elimination from Diphosphine Palladium Complexes

P. J. Guiry and J. M. Brown

Inorg. Chim. Acta, 1994, 220, 249-259

Chirality and the Metal-alkene Bond; Distortions in the Solution and Solid-state Structures of h²-Ethene Rhodium bis-Oxazolinylmethane Complexes

S. Karalulov, M. B. Hursthouse, D. W. Price, P. J. Guiry and J. M. Brown

Tetrahedron Asymmetry, 1994, 5, 561

1993

Stereochemistry of the Catalysed Diels-Alder Reaction between Cyclopentadiene and Dimethyl Monothionofumarate; Soft versus Hard Lewis Acids

P. J. Guiry, J. M. Brown and D. C. Braddock

J. Chem. Soc., Chem. Commun., 1993, 1244

The Origins of Enantioselectivity in Catalytic Asymmetric Synthesis

J. M. Brown, P. J. Guiry and A. Wienand

Principles of Molecular Recognition, Eds. S. M. Roberts, A. C., Legon, and A. D. Buckingham, Chapman and Hall, 1993, Chapter 4, pp.79-108

1992

Application of Aryllead(IV) Derivatives to the Preparation of 3-AryI-4-hydroxy-2H-1-benzopyran-2-ones

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

J. Chem. Soc., Perkin Trans. I, 1992, 1365-1375

1990

Aryllead Triacetates: Regioselective Reagents For N-Arylation of Amines

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron Lett., 1990, 31, 7449

Total Synthesis of Isorobustin

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron Lett., 1990, 31, 7449

Synthesis of 2-Aryl-3(2H)-Benzofuranones

J. M. Kietly, P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron Lett., 1990, 31, 6637

The Facile Synthesis of A Very Hindered Phenol by Ligand Coupling

J. H. Reibenspies, P. J. Guiry, D. M. X. Donnelly and D. H. R. Barton

J. Chem. Soc., Chem.Commun., 1990, 1110

1989

A Facile Synthesis of 3-AryI-4-Hydroxycoumarins

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron Lett., 1989, 30, 1539

Arylation of Amines By Aryllead Triacetates Using Copper Catalysis

P. J. Guiry, J. P. Finet, D. M. X. Donnelly and D. H. R. Barton

Tetrahedron Lett., 1989, 30, 1377